iPSCORE Analysis: Early Developmental Regulatory Variation Mashr Results

This file contains the mashr results run on the three early developmental iPSCORE tissues and 47 adult GTEx tissues. We used mashr to calculate the tissue-specificity of pairs of eGenes and their eQTL lead variants across all 50 tissues. The file contains the following columns; gene_variant the space-separated identifier for the Gencode gene ID and the eQTL lead variant, ntissues_tested the total number of tissues that the gene_variant was tested in, ntissues_significant the total number of tissues that the gene_variant was significant (local false sign rate [LFSR] < 0.05], nipscore_tested the number of iPSCORE tissues that the gene_variant was tested in, ngtex_tested the number of GTEx tissues that the gene_variant was tested in. The remaining columns contain the mashr-calculated LFSR values for the three iPSCORE tissues and 47 GTEx tissues.

本文件收录了针对早期发育阶段的 iPSCORE 组织以及 47 个成年 GTEx 组织进行 mashr 分析的结果。本研究利用 mashr 方法，对 50 个组织样本中成对 eGenes 及其 eQTL 主效应变异体的组织特异性进行了量化。文件中包含以下列：基因变异标识符，由 Gencode 基因 ID 与 eQTL 主效应变异体通过空格分隔构成的唯一标识；在测试中涉及的组织总数（ntissues_tested）；基因变异体显著的组织总数（ntissues_significant，其中局部假阳性率 [LFSR] 小于 0.05）；在 iPSCORE 组织中测试的基因变异体数量（nipscore_tested）；在 GTEx 组织中测试的基因变异体数量（ngtex_tested）。其余列包含了 mashr 方法针对三个 iPSCORE 组织和 47 个 GTEx 组织计算得到的 LFSR 值。