Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use [ABX-RNA seq]

To uncover the role of opioid induced dysbiosis in disrupting intestinal homeostasis, we conducted a multi-omics analysis with gut microbial, metabolite and intestinal transcriptomics data Overall design: We identified morphine-microbiome mediated changes in host gene expression changes in morphine treated and microbiome depleted morphine treatment (ABX_morphine) using RNA sequencing.