Structure of bovine endothelial nitric oxide synthase heme domain in complex with2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(3-cyanobenzyl) ethan-1-amine

Structure of bovine endothelial nitric oxide synthase heme domain in complex with2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(3-cyanobenzyl) ethan-1-amine Descriptor: 3-[({2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}amino)methyl]benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... Authors: Li, H, Poulos, T.L. Deposit date: 2014-10-20 Release date: 2014-12-24 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015

牛内皮型一氧化氮合酶血红素结构域与2-(2-(1H-咪唑-1-基)嘧啶-4-基)-N-(3-氰基苄基)乙-1-胺的复合物结构。描述项：3-[({2-[2-(1H-咪唑-1-基)嘧啶-4-基]乙基}氨基)甲基]苯甲腈、5,6,7,8-四氢生物蝶呤、乙酸根离子…… 作者：Li, H、Poulos, T.L. 提交日期：2014-10-20 发布日期：2014-12-24 最后修改日期：2024-10-23 实验方法：X射线衍射（分辨率2埃） 引用文献：《新型2,4-二取代嘧啶类化合物作为强效、选择性且可透过细胞膜的神经元型一氧化氮合酶抑制剂》，《药物化学杂志》（*J. Med. Chem.*），58卷，2015年。