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Genome-wide CRISPR screen to identify modulators of POLQ inhibition in SUM149PT

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NIAID Data Ecosystem2026-03-14 收录
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SUM149PT were transduced with a genome-wide CRISPR ko library (TKO v3), following a 7 day selection period. Then, cells were treated with DMSO or 2-2.5uM of POLQ inhibitor for 18 days. 3 samples were sequenced:- early time point (after 5 days of puromycin selection)- end time point DMSO (after 18 days of treatment with DMSO)- end time point POLQi (after 18 days of treatment with POLQi)

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2022-11-02
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