Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73E mutant complexed with fluconazole

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G73E mutant complexed with fluconazole Descriptor: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE Authors: Sagatova, A, Keniya, M.V, Wilson, R.K, Sabherwal, M, Tyndall, J.D.A, Monk, B.C. Deposit date: 2015-11-16 Release date: 2016-11-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase. Antimicrob.Agents Chemother., 62, 2018

酿酒酵母（Saccharomyces cerevisiae）CYP51（羊毛甾醇14-α-去甲基化酶，Lanosterol 14-alpha demethylase）G73E突变体与氟康唑（fluconazole）的复合物。复合物标识物：2-(2,4-二氟苯基)-1,3-二(1H-1,2,4-三唑-1-基)丙-2-醇；靶蛋白为羊毛甾醇14-α-去甲基化酶，辅基为含Fe的原卟啉IX（PROTOPORPHYRIN IX CONTAINING FE）。作者：Sagatova A、Keniya M.V、Wilson R.K、Sabherwal M、Tyndall J.D.A、Monk B.C.。提交日期：2015-11-16；发布日期：2016-11-23；最后修改日期：2023-09-27。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.25埃（Å）。引用文献：《病原酵母同源耐药突变对酿酒酵母羊毛甾醇14α-去甲基化酶的影响》（"Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase"），刊载于《抗微生物剂与化疗》（Antimicrob.Agents Chemother.），第62卷，2018年。