Rabbit muscle glycogen phosphorylase b in complex with N-(indol-2- carbonyl)-N-beta-D-glucopyranosyl urea determined at 1.8 A resolution

Rabbit muscle glycogen phosphorylase b in complex with N-(indol-2- carbonyl)-N-beta-D-glucopyranosyl urea determined at 1.8 A resolution Descriptor: GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, N-[(1H-indol-2-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine, ... Authors: Chrysina, E.D, Nagy, V, Felfoldi, N, Konya, B, Telepo, K, Praly, J.P, Docsa, T, Gergely, P, Alexacou, K.M, Hayes, J.M, Konstantakaki, M, Kardakaris, R, Leonidas, D.D, Zographos, S.E, Oikonomakos, N.G, Somsak, L. Deposit date: 2012-11-21 Release date: 2013-12-11 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Synthesis, Kinetic, Computational and Crystallographic Evaluation of N-Acyl-N-Beta-D- Glucopyranosyl)Ureas, Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase, Potential Antidiabetic Agents To be Published

分辨率达1.8埃的兔肌肉糖原磷酸化酶b（glycogen phosphorylase b）与N-(吲哚-2-羰基)-N-β-D-吡喃葡萄糖基脲（N-(indol-2-carbonyl)-N-beta-D-glucopyranosyl urea）复合物的晶体结构解析。描述项：肌肉型糖原磷酸化酶：肌肉型糖原磷酸化酶（glycogen phosphorylase, muscle form）、N-[(1H-吲哚-2-基羰基)氨基甲酰]-β-D-吡喃葡萄糖胺（N-[(1H-indol-2-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine），……作者：Chrysina, E.D、Nagy, V、Felfoldi, N、Konya, B、Telepo, K、Praly, J.P、Docsa, T、Gergely, P、Alexacou, K.M、Hayes, J.M、Konstantakaki, M、Kardakaris, R、Leonidas, D.D、Zographos, S.E、Oikonomakos, N.G、Somsak, L. 入库日期：2012-11-21 发布日期：2013-12-11 最后更新时间：2023-12-20 实验方法：X射线衍射（X-RAY DIFFRACTION，1.83埃） 引用文献：《N-酰基-N-β-D-吡喃葡萄糖基脲类化合物的合成、动力学、计算及晶体学评价——纳摩尔级糖原磷酸化酶葡萄糖类似物抑制剂、潜在抗糖尿病候选药物》（待发表）