Antibodies to the TSHR and Tg induced in transgenic mice expressing high or low levels of the human TSHR A-subunit (Hi - and Lo- expressors) and wild-type (WT) littermates.

The data are shown graphically in Fig. 2. Values are the Mean+SEM (5–7 mice) in sera drawn after 32 and 74 days (euthanasia). The upper limits (mean+2 SEM) for wild-type mice immunized with control-adenovirus (n = 4): TSHR ELISA 0.35 OD; TBI, 26% inhibition; TgAb 0.6 OD. Statistically significant differences are shown in Fig. 2. Bold indicates positive values. None*: data for mice immunized 3× with A-sub-Ad are repeated to facilitate comparison with mice primed with CFA/Tg and CFA/PBS.