Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model
Many long noncoding RNAs (lncRNAs) are localized in the nucleus and play important roles in various biological processes, including cell proliferation, differentiation and antiviral response. Yet, it
Apoptotic protease activating factor 1 (Apaf-1) was traditionally defined as a scaffold proteinin mammalian cells for assembling a caspase activation platform known as the 'apoptosome' after its bindi
Analysis of mRNA-seq reveals how wild-type and Eral1 deficient peritoneal macrophages response to SeV infection Overall design: Primary peritoneal macrophages generated from WT or Eral1 knock down
Here we applied a systems approach to define human innate immune signatures following MRKAd5/HIV immunization and to analyze the effects of pre-existing Ad5 immunity. To determine whether vaccine-indu
An efficient innate immune recognition of the intracellular parasite T. cruzi is crucial for host protection against development of Chagas disease, which often leads to multiple organ damage, particul