Genome-wide identification of altered m6A-related transcript profiles for vascular tissue in septic rats

Sepsis is the leading cause of death in hospital intensive care units. Recent studies have shown that N6-methyladenosine (m6A) modification promotes the inflammatory response, and we evaluated the effect of lipopolysaccharide (LPS) on aortic m6A modifications in mRNAs and lncRNAs.脓毒症（Sepsis）是医院重症监护病房中最主要的致死病因。已有研究表明，N6-甲基腺苷（N6-methyladenosine，m6A）修饰可促进炎症反应；本研究评估了脂多糖（lipopolysaccharide，LPS）对主动脉组织中信使RNA（messenger RNA，mRNA）及长链非编码RNA（long non-coding RNA，lncRNA）的m6A修饰的影响。