Agent-based models predict emergent behavior of heterogeneous cell populations in dynamic microenvironments: POPULATION HETEROGENEITY (2/5)

Data and results for `POPULATION HETEROGENEITY` simulations. Simulations of all possible combinations of four populations (X, A, B, C) under colony and tissue context with different levels of parameter heterogeneity (0, 0.1, 0.2, 0.3, 0.4, and 0.5). For tissue context, the healthy cell populations also varies parameter heterogeneity independent of the cancerous cell populations. Each condition is run for 15 days (21600 ticks) with 20 replicates (random seeds 0 - 19). Cells are introduced to the center of the constant source environment after a 1 day delay. Snapshots are taken every 0.5 days (720 ticks). The data folder contains .tar.xz compressed replicate sets. The data.param folder contains .tar.xz compressed replicate sets for .PARAM output. The results folder contains .pkl files of data parsed into arrays. Simulations are labeled as: [context]_[populations]_[population heterogeneity]_[background heterogeneity] - [context] - C = colony context, cancerous cell populations only - CH = tissue context, cancerous cell populations and healthy cells - [populations] - X = cancerous cell population with basal parameters - A = cancerous cell population with max_height x 1.5 - B = cancerous cell population with meta_pref x 1.5 - C = cancerous cell population with migra_threshold x 0.5 - [population heterogeneity] - ## = heterogeneity value for cancerous cell populations (##/10) - [background heterogeneity] - ## = heterogeneity value for healthy cell population (##/10) Additional data and results for this simulation set available at: - doi: 10.17632/bk9s769t3t - doi: 10.17632/hskf9mxbpw - doi: 10.17632/ynzsfdswjz - doi: 10.17632/p46dwfyvzg本数据集为种群异质性（Population Heterogeneity）模拟所用的数据与结果。本数据集包含四种种群（X、A、B、C）的全部组合，分别在集落环境与组织环境下，以0、0.1、0.2、0.3、0.4、0.5共6种参数异质性水平开展模拟实验。其中在组织环境中，健康细胞种群的参数异质性设置与癌细胞种群相互独立。 每个实验条件均运行15天（对应21600个时间步），并设置20次重复实验（随机种子取值为0至19）。细胞将在1天延迟后被引入恒定源环境的中心。每0.5天（720个时间步）采集一次模拟快照。 数据文件夹内存储以.tar.xz格式压缩的重复实验数据集；data.param文件夹内存储用于输出.PARAM格式文件的.tar.xz格式压缩重复实验数据集；results文件夹内存储已解析为数组格式的.pkl格式数据文件。 模拟实验的命名格式为：[环境类型]_[种群类型]_[种群异质性水平]_[背景异质性水平]。各字段说明如下： - 环境类型：C代表仅包含癌细胞种群的集落环境；CH代表同时包含癌细胞种群与健康细胞的组织环境 - 种群类型：X为采用基础参数的癌细胞种群；A为将最大高度（max_height）参数放大1.5倍的癌细胞种群；B为将迁移偏好（meta_pref）参数放大1.5倍的癌细胞种群；C为将迁移阈值（migra_threshold）参数调整为原值0.5倍的癌细胞种群 - 种群异质性水平：两位数字，代表癌细胞种群的异质性数值（实际取值为##/10） - 背景异质性水平：两位数字，代表健康细胞种群的异质性数值（实际取值为##/10） 本模拟集的额外数据与结果可通过以下DOI获取： - doi: 10.17632/bk9s769t3t - doi: 10.17632/hskf9mxbpw - doi: 10.17632/ynzsfdswjz - doi: 10.17632/p46dwfyvzg