RNAseq measurement of cortisol induced gene expression change under knockout of glucocorticoid receptor (nr3c1)
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE144884
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We found that GR mediates most of the effects of the treatment, and paradoxically, that the transcriptome of cortisol-treated larvae is more like that of larvae lacking a GR than that of larvae with a GR, suggesting that the cortisol-treated larvae develop GR resistance. To assess the role of the Glucocorticoid Receptor (GR) in such programming, we used CRISPR-Cas9 to produce a new frameshift mutation, GR369-.
创建时间：
2020-07-15
