In the cell, stalled ribosomes are rescued through ribosome-associated protein quality-control (RQC) pathways. We demonstrate that RqcH is responsible for tRNAAla selection during RQC elongation, wher

NIAID Data Ecosystem60

Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation

内质网相关降解

蛋白质质量控制

Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transpor

Figshare2019-01-25 更新20

Genome-wide CRISPR-Cas9 screen (TKOv3) data on CYP51A1TM degradation

蛋白质质量控制

ERAD途径

Misfolded proteins in the endoplasmic reticulum (ER) are degraded by ER-associated degradation (ERAD). While ERAD components involved in degradation of luminal substrates are well-characterized, much

NIAID Data Ecosystem70

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex

ERAD内质网相关降解

蛋白质质量控制

Structural coordinates, cryo-EM maps, and PDB validation reports for the OS9-SEL1L-HRD1 ERAD core complex. Maps were filtered to 4A for visualization. Half-maps have also been provided.

DataCite Commons2026-02-28 更新30

Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants

资源简介：

相关数据集