Dobutamine improves hemodynamics and oxygen delivery in standing and isoflurane-anesthetized horses

Background: Dobutamine is a first-line therapy for hypotension in anesthetized horses, but effects on hemodynamic parameters in standing and anesthetized horse are not well studied.
Objectives: To investigate effects of dobutamine in escalating dosages on hemodynamic performance in awake and anesthetized horses.
Study Design: Randomized cross-over experimental study.
Methods: Six healthy adult horses were enrolled including both standing and isoflurane-anesthetized experiments with one week washout. Heart rate, mean arterial pressure (MAP), central venous pressure, pulmonary arterial pressure, and thermodilution cardiac output (CO) were measured at baseline and at dobutamine infusion rates of 0.5, 1, and 2 mcg/kg/min. Arterial and mixed-venous blood was sampled and oxygen delivery (DO2), oxygen extraction ratio (O2ER), and fShunt were calculated. After confirming normal distribution variables were compared to baseline and between groups using two-factorial ANOVA (alpha = 5%).
Results: M..., , , # Dobutamine improves hemodynamics and oxygen delivery in standing and isoflurane-anesthetized horses
[https://doi.org/10.5061/dryad.cnp5hqcdz](https://doi.org/10.5061/dryad.cnp5hqcdz)

## Description of the data and file structure

Six healthy adult horses were enrolled including both standing and isoflurane-anesthetized experiments with one week washout. Heart rate, mean arterial pressure (MAP), central venous pressure, pulmonary arterial pressure, and thermodilution cardiac output (CO) were measured at baseline and at dobutamine infusion rates of 0.5, 1, and 2 mcg/kg/min. Arterial and mixed-venous blood was sampled and oxygen delivery (DO2), oxygen extraction ratio (O2ER), and fShunt were calculated After confirming normal distribution variables were compared to baseline and between groups using two-factorial ANOVA (alpha = 5%).

## Access information

Other publicly accessible locations of the data:

* na

Data was derived from the following sources:

* healthy research animals