Dobutamine improves hemodynamics and oxygen delivery in standing and isoflurane-anesthetized horses

Background: Dobutamine is a first-line therapy for hypotension in anesthetized horses, but effects on hemodynamic parameters in standing and anesthetized horse are not well studied. Objectives: To investigate effects of dobutamine in escalating dosages on hemodynamic performance in awake and anesthetized horses. Study Design: Randomized cross-over experimental study. Methods: Six healthy adult horses were enrolled including both standing and isoflurane-anesthetized experiments with one week washout. Heart rate, mean arterial pressure (MAP), central venous pressure, pulmonary arterial pressure, and thermodilution cardiac output (CO) were measured at baseline and at dobutamine infusion rates of 0.5, 1, and 2 mcg/kg/min. Arterial and mixed-venous blood was sampled and oxygen delivery (DO2), oxygen extraction ratio (O2ER), and fShunt were calculated. After confirming normal distribution variables were compared to baseline and between groups using two-factorial ANOVA (alpha = 5%). Results: M..., , , # Dobutamine improves hemodynamics and oxygen delivery in standing and isoflurane-anesthetized horses [https://doi.org/10.5061/dryad.cnp5hqcdz](https://doi.org/10.5061/dryad.cnp5hqcdz) ## Description of the data and file structure Six healthy adult horses were enrolled including both standing and isoflurane-anesthetized experiments with one week washout. Heart rate, mean arterial pressure (MAP), central venous pressure, pulmonary arterial pressure, and thermodilution cardiac output (CO) were measured at baseline and at dobutamine infusion rates of 0.5, 1, and 2 mcg/kg/min. Arterial and mixed-venous blood was sampled and oxygen delivery (DO2), oxygen extraction ratio (O2ER), and fShunt were calculated After confirming normal distribution variables were compared to baseline and between groups using two-factorial ANOVA (alpha = 5%). ## Access information Other publicly accessible locations of the data: * na Data was derived from the following sources: * healthy research animals研究背景：多巴酚丁胺（dobutamine）是麻醉马匹低血压的一线治疗药物，但目前对于其对站立状态与麻醉状态下马血流动力学参数的影响尚未得到充分研究。 研究目的：探究不同递增剂量的多巴酚丁胺对清醒与麻醉马匹血流动力学状态的影响。 研究设计：随机交叉试验研究。 研究方法：纳入6匹健康成年马匹，分别开展站立状态与异氟烷麻醉状态下的试验，两组之间设置1周的洗脱期。在基线状态以及多巴酚丁胺输注速率为0.5、1、2 mcg/kg/min时，测量心率、平均动脉压（mean arterial pressure, MAP）、中心静脉压、肺动脉压以及热稀释心输出量（thermodilution cardiac output, CO）。采集动脉血与混合静脉血样本，并计算氧输送量（oxygen delivery, DO2）、氧摄取率（oxygen extraction ratio, O2ER）以及fShunt。确认数据符合正态分布后，采用双因素方差分析（检验水准α=5%）对各组数据与基线状态的差异以及组间差异进行比较。 研究结果：[原文内容缺失]# 多巴酚丁胺可改善站立状态与异氟烷麻醉马匹的血流动力学状态与氧输送能力。 https://doi.org/10.5061/dryad.cnp5hqcdz 数据集与文件结构说明：纳入6匹健康成年马匹，分别开展站立状态与异氟烷麻醉状态下的试验，两组之间设置1周的洗脱期。在基线状态以及多巴酚丁胺输注速率为0.5、1、2 mcg/kg/min时，测量心率、平均动脉压（MAP）、中心静脉压、肺动脉压以及热稀释心输出量（CO）。采集动脉血与混合静脉血样本，并计算氧输送量（DO2）、氧摄取率（O2ER）以及fShunt。确认数据符合正态分布后，采用双因素方差分析（α=5%）对各组数据与基线状态的差异以及组间差异进行比较。 数据获取信息：该数据集的其他公开获取渠道：无。本数据集源自以下来源：健康实验动物。