Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

The dataset contains the repertoire sequencing data from 45 adult volunteers.For each case 4 separate TCR repseq libraries were constructed after cDNA synthesis using a UMI containing primer located in the constant exon of the TRA, TRD, TRB and TRG genes respectively. In each case a 5’ multiplex set of primers specific for the leader regions of the V genes of either TRA, TRD, TRB or TRG genes was used along with a universal reverse primer, introduced during the cDNA synthesis step to produce the gene specific repseq library.The libraries were sequenced using the Illumina 2 x 300 cycle MiSeq system at the Karlsson Hedestam Laboratory at the Department of Microbiology, Tumor and Cell Biology at Biomedicum, Karolinska Institutet, Stockholm. <br><br><b>Terms for access</b>The datasets are only to be used for research that is seeking to advance the understanding of the influence of TCR genetic variation on human biology.<br><br>