Physiological adaptations to sugar-mimic alkaloids: insights from Bombyx mori for long-term adaption and short-term response

Plant-insect interaction is a dynamic system, insects evolved adaptive plasticity to minimize the effects of the chemical defenses of their host plants. Nevertheless, the expressional response and adaptation of phytophagous specialists for long-term adaption and short-term response to host phytochemicals remains largely unexplored. The mulberry (Morus alba) -silkworm (Bombyx mori) interaction is an old and well-known model of plant-insect interaction. In this study, we examined the long-term adaption and short-term response of the mulberry-specialist silkworm to two sugar-mimic alkaloids in mulberry: the commonly encountered 1-deoxynojirimycin (1-DNJ) and occasionally encountered 1,4-dideoxy-1,4-imino-D-arabinitol (D-AB1), respectively. Global transcriptional patterns revealed that the physiological responses induced by the selective expression of genes involved in manifold cellular processes, including detoxification networks, canonical digestion processes, target enzymes and other fun...植物-昆虫互作是一类动态系统，昆虫通过演化出适应性可塑性，以削弱宿主植物化学防御所产生的负面影响。然而，植食性专食昆虫针对宿主植物化学物质的长期适应与短期响应的表达调控及适应机制，目前仍未得到充分探索。桑树（Morus alba）-家蚕（Bombyx mori）互作是一类经典且广为人知的植物-昆虫互作模型。本研究以桑树专食性昆虫家蚕为对象，探究其对桑树中两种糖模拟生物碱的长期适应与短期响应：分别为常见的1-脱氧野尻霉素（1-deoxynojirimycin，1-DNJ）以及偶见存在的1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇（D-AB1）。全局转录谱显示，涉及解毒网络、经典消化过程、靶标酶及其他多种细胞过程的基因经选择性表达可诱导产生相应生理响应，包括...