Exploring the intrinsic mechanisms of Omphalia lapidescens sclerotium in treating epilepsy based on multi-omics mendelian randomization and bioinformatics methods

Covering the results of multi omics Mendelian randomization analysis of public data on epilepsy, as well as microarray data analysis. The specific content is as follows: Table 1-S1-TCMSP database shows the screened active ingredients and corresponding targets of Lei Wan; Appendix 1-S2- Selected eQTL Data (cis expression quantitative trait locus data from 5311 peripheral blood samples of individuals with European ancestry); Appendix 1-S3- pQTL data after screening (this study conducted a genome-wide association study on plasma protein levels in 35559 Icelandic individuals, using 4907 aptamers for measurement); Appendix 1-S4- Effective Results of IVW Method for MR Analysis of eQTL and pQTL Data with Two Epilepsy GWAS Data (pval<0.05); Table 1-S5-2 Differential expression analysis results of microarray datasets and their merged microarray datasets (this study was conducted from GEO database)（ https://www.ncbi.nlm.nih.gov/geo/ ）Barrett et al. (2013) obtained two independent epilepsy related microarray datasets. The GSE143272 data is sourced from the research conducted by the Erin L Heinzen team; The GSE31718 data was submitted by Hsin Y et al. and includes 30968 annotated human gene expression profiles from 10 patient brain samples. ）； Attachment 1-S6-GO/KEGG Enrichment Analysis; Appendix 1-MR Results of Regulating Intestinal Microbiota with S7-RORA and PTGS2.