Radical Carbofluorination of Unactivated Alkenes with Fluoride Ions
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https://figshare.com/articles/dataset/Radical_Carbofluorination_of_Unactivated_Alkenes_with_Fluoride_Ions/6227426
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资源简介：
The
copper-assisted radical carbofluorination of unactivated alkenes
with fluoride ions is described. With [Cu(L3)F2]H2O (L3 = 4,4′-di(methoxycarbonyl)-2,2′-bipyridine)
as the fluorine source and [Ag(DMPhen)(MeCN)]BF4 (DMPhen
= 2,9-dimethyl-1,10-phenanthroline) as the chloride scavenger, the
reaction of unactivated alkenes with CCl4 in acetonitrile
provided the corresponding carbofluorination products in satisfactory
yields. The protocol exhibited a wide functional group compatibility
and broad substrate scope and could be extended to the use of a variety
of activated alkyl chlorides other than CCl4. A copper-catalyzed
fluorotrifluoromethylation of unactivated alkenes was then successfully
developed with CsF as the fluorine source and Umemoto’s reagent
as the trifluoromethylating agent. A mechanism involving the fluorine
atom transfer from Cu(II)–F complexes to alkyl radicals is
proposed.
创建时间：
2018-05-07
