Antibiotics-induced alterations of gut microbiome emancipate the insulin resistance in iNOS knockout mice

Inducible nitric oxide synthase (iNOS), a mediator of inflammation, has emerged as a metabolic regulator. Recent studies demonstrated metabolic perturbations in iNOS-/- mice highlighting importance of optimal redox balance. As host genetics and altered metabolism regulates composition and ecosystem of gut microbiome, we examined the role of gut microbiome in iNOS-/- mice as compared to WT.