Associations between cytokine levels in plasma and behavior as determined by linear regression analyses.

Several associations were found between systemically circulating inflammatory markers and behavior. Statistically significant linear regressions revealed that high levels of IL-6 was related to poor memory performance, and high levels of IL-12p70 increased anxiety in the triple test, measured by increased numbers of peaks into the light box, without entering, and decreased time spent in the light box. IL-17A is associated with amount of sucrose consumption and memory. Behavior was not correlated to IL-1β, IL-10 and TNF-α, as all samples were at basal concentrations regarding these cytokines. Not shown and non-significant are: In the triple test; Time spent in center of OF, time spent on OA, risk assesment to OA, and in the FST; Latency to and time spent immobile. Italic: negative correlation. Bold: Positive correlation.