Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB

Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate Authors: Zhu, J.-Y, Ember, S.W, Watts, C, Schonbrunn, E. Deposit date: 2013-12-24 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014

人类BRD4首个溴结构域（bromodomain）与福斯塔替尼（FOSTAMATINIB）结合的晶体结构。描述组分：1,2-乙二醇、含溴结构域蛋白4（Bromodomain-containing protein 4）、[6-({5-氟-2-[(3,4,5-三甲氧基苯基)氨基]嘧啶-4-基}氨基)-2,2-二甲基-3-氧代-2,3-二氢-4H-吡啶并[3,2-b][1,4]恶嗪-4-基]甲基二氢磷酸酯。作者：Zhu, J.-Y、Ember S.W、Watts C、Schonbrunn, E。提交日期：2013-12-24，发布日期：2014-03-05，最后修改日期：2023-09-20。实验方法：X射线衍射（分辨率1.55埃）。引用文献：《含溴结构域蛋白4（BRD4）的乙酰赖氨酸结合位点与多种激酶抑制剂相互作用》，发表于《ACS Chem.Biol.》，2014年，第9卷。