Fuentealb2016 - Genome-scale metabolic reconstruction (iPF215) of Piscirickettsia salmonis LF-89

Fuentealb2016 - Genome-scale metabolic
reconstruction (iPF215) of Piscirickettsia salmonis LF-89

This model is described in the article:

Genome-scale metabolic
reconstruction for the insidious bacterium in aquaculture
Piscirickettsia salmonis.

Fuentealba P, Aros C, Latorre Y,
Martínez I, Marshall S, Ferrer P, Albiol J, Altamirano
C.
Bioresour. Technol. 2017 Jan; 223:
105-114
Abstract:

Piscirickettsia salmonis is a fish bacterium that causes the
disease piscirickettsiosis in salmonids. This pathology is
partially controlled by vaccines. The lack of knowledge has
hindered its culture on laboratory and industrial scale. The
study describes the metabolic phenotype of P. salmonis in
culture. This study presents the first genome-scale model
(iPF215) of the LF-89 strain of P. salmonis, describing the
central metabolic pathway, biosynthesis and molecule
degradation and transport mechanisms. The model was adjusted
with experiment data, allowing the identification of the
capacities that were not predicted by the automatic annotation
of the genome sequences. The iPF215 model is comprised of 417
metabolites, 445 reactions and 215 genes, was used to reproduce
the growth of P. salmonis (?max 0.052±0.005h(-1)). The
metabolic reconstruction of the P. salmonis LF-89 strain
obtained in this research provides a baseline that describes
the metabolic capacities of the bacterium and is the basis for
developing improvements to its cultivation for vaccine
formulation.

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