Single cell RNA sequencing for α lymphoid progenitor

The single-cell transcriptional analysis of bone marrow progenitors and subsequent analysis revealed that GATA3 induction in late ILC2-committed precursor depends on the G3SE lesion and that the upregulation of GATA3 in the late ILC2-precursor is required for the transition to mature ILC2. Single cell RNA-sequencing was performed in α lymphoid progenitor of WT mice and G3SEKO (GATA3-related tandem Super-Enhancers Knock-Out) mice