A Versatile Synthesis of Fluorinated Uracils in Solution and on Solid-Phase
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https://figshare.com/articles/dataset/A_Versatile_Synthesis_of_Fluorinated_Uracils_in_Solution_and_on_Solid_Phase/3341329
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资源简介：
An efficient and convenient two-step synthesis of new fluorinated uracils is described. The first step involves the condensation of an ester
enolate with a fluorinated nitrile to furnish fluorinated β-enamino esters. In turn, these compounds react with organic isocyanates or
isothiocyanates to give C-6 fluorinated uracils or thiouracils, respectively, in excellent yields. This synthesis has been successfully adapted
to solid-phase conditions with high diversity, thereby facilitating the creation of small (thio)uracil libraries.
创建时间：
2016-05-07
