Protein arginine transferase 5 (PRMT5) has been implicated as an important modulator of tumorigenesis as it promotes tumor cell proliferation, invasion, and metastasis. Studies have largely focused on
Radiotherapy enhances systemic responses to anti-CTLA-4 antibodies in pre-clinical studies and in some melanoma patients, but its efficacy in inducing systemic responses against tumors unresponsive to
We uncovered an essential role of radiationtherapy (RT)-activated lung residential Scgb1a1+ club cells in synergizing efficacy of immuno-checkpoint inhibitors. We explored the mechanisms underlying RT
