Crystal structure of S. aureus tryptophanyl-tRNA synthetase complexed with 3-methylchuangxinmycin

Crystal structure of S. aureus tryptophanyl-tRNA synthetase complexed with 3-methylchuangxinmycin Descriptor: (6~{R})-5,5-dimethyl-7-thia-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(12),3,8,10-tetraene-6-carboxylic acid, Tryptophan--tRNA ligase Authors: Ren, Y, Qiao, H, Wang, S, Liu, W, Fang, P. Deposit date: 2024-12-06 Release date: 2025-07-23 Last modified: 2025-09-03 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin. Rsc Chem Biol, 6, 2025金黄色葡萄球菌（S. aureus）色氨酰-tRNA合成酶与3-甲基创新霉素（3-methylchuangxinmycin）结合的晶体结构 配体描述：(6R)-5,5-二甲基-7-硫杂-2-氮杂三环[6.3.1.0^{4,12}]十二烷-1(12),3,8,10-四烯-6-羧酸；该复合物对应色氨酸-tRNA连接酶（Tryptophan--tRNA ligase） 作者：Ren Y、Qiao H、Wang S、Liu W、Fang P 入库日期：2024-12-06 发布日期：2025-07-23 最后修改日期：2025-09-03 检测方法：X射线衍射（2.21埃） 引用文献：创新霉素介导的ATP依赖型及物种特异性色氨酰-tRNA合成酶抑制机制研究，Rsc Chem Biol，6，2025