Additional file 2 of The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson’s disease comorbidity

Additional file 2. Table S1. Sample-level QC metrics of the IBD-PD cohort. Table S2. BioMe participants by ancestry. Table S3. Minor allele frequencies of the LRRK2 variants. Table S4. Variant-level association tests of LRRK2 variants. Table S5. HGMD classification of the LRRK2 missense variants. Table S6. SKAT-O results. Table S7. NHC results. Table S8. Known IBD and PD genes and 120 significant genes from SKAT-O and NHC analysis of IBD-PD cohort. Table S9. IPA canonical pathway enrichment analysis of 120 SKAT-O and NHC significant IBD-PD genes, known IBD genes and known PD genes. Table S10. Gene prioritization according to 4 biological relatedness and pathway approaches. Table S11. InnateDB pathway enrichment analysis. Table S12. InnateDB GO enrichment analysis. Table S13. Biological importance scores for IBD-PD. Table S14. Biological importance scores for PD. Table S15. Biological importance scores for IBD. Table S16. Presumably deleterious rare variants located in the 14 candidate genes identified in the IBD-PD cohort. Table S17. PheWAS of 14 candidate genes in BioMe BioBank. Table S18. PheWAS of 14 candidate genes in UK Biobank.