Single-walled vs. Multi-walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs

Transcriptional profiling of mouse lung tissue comparing control vs exposure to different carbon nanotubes. The aim was to determine if the physico-chemical properties influence the genotoxic, inflammatory and pro-fibrotic responses. Purified and extracted RNA from lung tissue of female mice C57BL/6J BomTac aged 6-7 weeks exposed for 24 hours to different single-walled carbon nanotubes (SWCNTs) or multi-walled carbon nanotubes (MWCNTs) by single intratracheal instillation of 6, 18 or 54 μg/mouse. n= 8 control group, n=5 each dose group.