Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution.

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution. Descriptor: (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid, (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid, CITRATE ANION, ... Authors: Laulumaa, S, Frydenvang, K.A, Winther, S, Kastrup, J.S. Deposit date: 2017-03-17 Release date: 2017-07-26 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Structure and Affinity of Two Bicyclic Glutamate Analogues at AMPA and Kainate Receptors. ACS Chem Neurosci, 8, 2017

分辨率为1.15埃的GluA2配体结合结构域（S1S2J）与激动剂CIP-AS复合物的晶体结构。配体信息：(2S,3R,4R)-3-(羧基羰基)-4-羟基吡咯烷-2-羧酸、(3aS,4S,6aR)-4,5,6,6a-四氢-3aH-吡咯并[3,4-d][1,2]恶唑-3,4-二羧酸、柠檬酸根阴离子……作者：Laulumaa, S、Frydenvang, K.A、Winther, S、Kastrup, J.S。提交日期：2017-03-17，发布日期：2017-07-26，末次修改日期：2024-11-06。实验方法：X射线衍射（1.15 Å）。引用文献：《两种双环谷氨酸类似物在AMPA与红藻氨酸受体上的结构与亲和力》，《ACS化学神经科学》，第8卷，2017年