A new Sr(II)-based coordination polymer: structural insight and anti-gastric cancer activity

In this work, a new Sr(II)-based coordination polymer (CP) with the chemical formula of [Sr3(L)2(H2O)4] (1) (H3L = 4'-hydroxy-[1,1'-biphenyl]-3,3',5-tricarboxylic acid) has been successfully prepared by reaction of Sr(NO3)2 with the non-planar tripodal carboxylate ligand H3L in a mixed solvent of DMF and water. Furthermore, an ultrasonic treatment method was used to produce the crystalline samples in nanometer region. After treated with nano complex, the cell proliferation of MKN45 gastric cancer cells was detected by the Cell Counting Kit-8 (CKK-8) assay. In addition to this, the Annexin V-FITC/PI apoptosis detection Kit was performed in flow cytometer to measure the percentage of the apoptotic MKN45 cells after nano complex treatment. Finally, the expression of the apoptotic proteins was detected by western blot.