Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units
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https://figshare.com/articles/dataset/Production_of_Antitubercular_Depsipeptides_via_Biosynthetic_Engineering_of_Cinnamoyl_Units/12202385
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资源简介：
Two new cyclodecapeptides, atratumycins
B (1) and
C (2), containing substituted cinnamoyl side chains were
generated by converging elements of the atratumycin (3) and atrovimycin (4) biosynthetic pathways. The structures
of 1 and 2 were determined on the basis
of HRESIMS, 1D and 2D NMR data, and X-ray single-crystal diffraction
studies. Atratumycin B (1) is active against autoluminescent Mycobacterium tuberculosis H37Rv, displaying a minimum inhibitory
concentration of 3.1 μg/mL (2.3 μM).
创建时间：
2020-04-27
