Pan-HSV-2 IgG antibody levels correlate with protection against vaginal HSV-2 MS challenge in mice and guinea pigs.

aAnimals were immunized with each immunogen, as described in Figures 3A and 4A.bNaive and immunized mice correspond to animals presented in Figure 3; guinea pigs correspond to animals presented in Figure 4.cMean ± sem of log (pan-HSV-2 IgG) for mice correspond to x-variables in Figure 3C, and for guinea pigs correspond to x-variables in Figure 4C.dMean ± sem of log (reduction in vaginal HSV-2 shedding) in mice was derived from the y-variables presented in Figure 3C, and for guinea pigs was derived from the y-variables presented in Figure 4C.eFrequency of animals that survived until Day 30 post-HSV-2 vaginal challenge.fNot determined.*p**p†p = 0.01, as determined by Fisher's Exact Test comparing the frequency of survival of immunized versus naïve animals of the same species.††p = 0.00001, as determined by Fisher's Exact Test comparing the frequency of survival of immunized versus naïve animals of the same species.