Role of the RprY Response Regulator in P. gingivalis Community Development and Virulence

Porphyromonas gingivalis expresses a limited number of two-component systems, including RprY, an orphan response regulator that lacks a cognate sensor kinase. In this study, we examimed the regulon controlled by RprY and found that RprY can control the expression of genes encoding the type IX secretion system (T9SS) machinery and virulence factors secreted through the T9SS, including the gingipain proteases and peptidylarginine deiminase (PPAD). Five biological replicates each of WT and ΔrprY mutant P. gingivalis ATCC 33277 strain