Candidate non-synonymous mechanism SNPs in the Chromosome 3 locus associated with increased risk of Crohn's disease.

aProfile and stability impact scores are the outputs from the sequence profile and structure stability support vector machines respectively. Positive scores reflect an assignment of a low or negligible impact on in vivo protein function, negative scores an assignment of high impact on protein function. The higher the absolute score, the higher the confidence of the assignment. Scores >|0.5| are considered high confidence. NA indicates there is inadequate sequence or structure information available to make an assignment. (See Methods and [5] for details). Only the SNP in MST1 is assigned a high impact on protein function.