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Catalytic Enantioselective Synthesis of Flavanones and Chromanones

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Catalytic_Enantioselective_Synthesis_of_Flavanones_and_Chromanones/3014710
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The enantioselective synthesis of flavanones and chromanones is described. Bifunctional thiourea catalysts promote an asymmetric oxo-conjugate addition to a β-ketoester alkylidene in high yields with excellent enantioselectivity (80−94% ee) for aryl and alkyl substrates. Decarboxylation of the β-ketoester proceeds smoothly in a one-pot procedure to afford the enantioenriched flavanones and chromanones.
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2007-04-04
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