Host genetic factors and severity of Andes orthohantavirus infection: a genome wide association study

Andes orthohantavirus (ANDV) is an important human pathogen that cause hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Clinical course may present as a mild or severe illness. The influence of genetic factors of the host in the different clinical courses is currently poorly understood. Our goal was to identify copy number variats (CNVs) associated with different clinical courses (mild or severe) in patients infected with ANDV. We recruited 195 patients (88 mild and 107 severe). Genotyping was performed using Affymetrix Genome-Wide SNP Array 6.0. We performed CNVs Genome Wide Association (GWAs) analisys.