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Effect of Bcl11b deletion in resting and activated mouse CD4+ T cells.

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE223334
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To investigate the function of Bcl11b in activated C57Bl/6 mouse CD4+ T cells, we deleted Bcl11b in vivo using a Bcl11b-fl/fl;Cd4cre-ert2 tamoxifen-inducible strategy. We then cultured CD4 T cells isolated from these mice 3 days in resting or activating condtions. Finally, we performed gene expression profiling analysis using data obtained from RNA-seq of 3-5 samples per genotype per condition. Comparative gene expression profiling analysis of RNA-seq data for mouse CD4+ T cells resting or stimulated in vitro 3 days. Bcl11b was deleted in vivo using a CD4-cre-ert2 system via tamoxifen injection.
创建时间:
2023-01-20
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