Deciphering responses of the fetal suprachiasmatic nuclei to the rhythmic maternal signals using omics approach

We report circadian (time series, circadian time 0, 3, 6, 9, 12, 18, 21h) transcriptomic analysis of mouse fetal (embryonic day 17) suprachiasmatic nuclei (SCN) from either sham operarated ad libitum fed mothers (group A) or from SCN-lesioned mothers on resctricted feeding regime. The analysis revealed low amplitude rhythms in the fetal SCN driven by maternal SCN and/or maternal feeding behavior. Examination of fetal SCN tissue from two groups of mothers on different feeding regime with intact or destroyed cental pacemaker, by RNAseq in a time series