Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosyl-L-homocysteine (SAH) and 1,4-dihydroxy-2-naphthoic acid (DHN)

Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosyl-L-homocysteine (SAH) and 1,4-dihydroxy-2-naphthoic acid (DHN) Descriptor: 1,4-dihydroxy-2-naphthoic acid, GLYCEROL, O-methyltransferase, ... Authors: Cooke, H.A, Bruner, S.D. Deposit date: 2009-07-06 Release date: 2009-09-01 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry, 48, 2009

来源于新制癌菌素生物合成途径的O-甲基转移酶（O-methyltransferase，NcsB1）与S-腺苷-L-同型半胱氨酸（S-adenosyl-L-homocysteine，SAH）及1,4-二羟基-2-萘甲酸（1,4-dihydroxy-2-naphthoic acid，DHN）形成复合物的晶体结构。描述符：1,4-二羟基-2-萘甲酸、甘油、O-甲基转移酶…… 作者：Cooke, H.A.、Bruner, S.D.。沉积日期：2009-07-06；发布日期：2009-09-01；最后修改日期：2023-09-06。测试方法：X射线衍射（X-RAY DIFFRACTION，分辨率3埃）。引用文献：《参与烯二炔类抗肿瘤抗生素新制癌菌素生物合成的S-腺苷甲硫氨酸（SAM）依赖型O-甲基转移酶NcsB1的底物泛质性分子机制》，《Biochemistry》，2009年，第48卷。