Table S1 - A Resource for Discovering Specific and Universal Biomarkers for Distributed Stem Cells

Self-renewal pattern associated (SRPA) genes, including the 85-gene asymmetric self-renewal associated (ASRA) gene signature. Expression data and annotation of all genes found to be significantly differentially regulated by the described RankProd intersection analysis is presented (See Materials and Methods). A RankProd percent false positive (pfp) cutoff of 0.05 was used. The expression values are given as log2 values. The fold change (FC; based on log2 values) refers to the average ratio of probe intensities on the ASYM chips to corresponding probe intensities the SYM chips. Genes are grouped based on the comparison in which they are differentially regulated. Genes up-regulated in the “A” (ASYM vs. SYM) and “B” (ASYM vs. p53SYM) comparisons are listed as ASRA_up; those that are down-regulated in these two comparisons are listed as ASRA_down. Genes that are up-regulated in only one comparison are listed in the A_up or B_up sections, and conversely genes that are down-regulated in only one comparison are listed in the A_down or B_down sections. Some genes are up-regulated in one comparison, but down-regulated in the other (i.e., if SYM>ASYM>p53SYM or if p53SYM>ASYM>SYM). These appear in the last two sections. Detection calls – whether expression is “present,” “marginal,” or “absent” (P, M, or A) – are summarized in columns immediately following the log2 expression values. If the call is A for all replicate chips for a self-renewal condition, the value cells are shaded; and if the call is P for all chips, the value cells are unshaded. If the calls are all M, or if they differ among replicate chips, an exclamation mark is given followed by the individual replicate calls. Data on the localization of the gene products was obtained from LOCATE [1]. “Type I” indicates that the protein is predicted to have one transmembrane domain, but does not have a signal peptide; and “type II” indicates that the protein is predicted to have a signal peptide and a transmembrane domain. In some instances, isoforms from the same gene are predicted or known to have different subcellular localizations. In these cases, multiple subcellular localization indicators appear. (XLS)