Enantioselective Vinylogous Michael–Michael Cascade Reactions of 3‑Alkylidene Oxindoles and Nitroolefin Enoates
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https://figshare.com/articles/dataset/Enantioselective_Vinylogous_Michael_Michael_Cascade_Reactions_of_3_Alkylidene_Oxindoles_and_Nitroolefin_Enoates/5167354
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资源简介：
A novel bifunctional squaramide catalyzed
vinylogous Michael–Michael
cascade reaction of 3-alkylidene oxindoles with nitroolefin enoates
was developed. This convenient, one-pot cascade reaction serves as
a powerful tool for the enantioselective construction of potential
bioactive chiral chromans, which have three continuous tertiary stereocenters,
in moderate to good yields (up to 85%) with excellent stereoselectivities
(up to >19:1 dr and >99% ee).
创建时间：
2017-07-03
