Optimization of Expanded NK Cells

NIAID Data Ecosystem2026-05-01 收录

NK细胞扩增

过继细胞免疫治疗

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1066840 数据链接链接失效反馈

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资源简介：

Starting populations of canine bulk PBMCs and CD5-depleted cells underwent a fourteen-day expansion to obtain an NK cell product for adoptive cell transfer.

创建时间：

2024-01-19

NK细胞体外规模化扩增的数据集

NK细胞扩增

免疫治疗

一、单个核细胞的制备：健康供者/患者外周血、脐带血、胎盘血，经密度梯度离心法获取单个核细胞。二、细胞大量扩增：使用无血清培养基，在37°C、5% CO₂恒温培养条件下，维持最佳细胞密度（通常1-2×10⁶ cells/mL）。每天换液，补充新鲜细胞因子进行规模化扩增，培养14天后进行数量与活力、纯度、表型验证。三、数据处理与分析：流式细胞术鉴定NK细胞表面标志（CD3-CD56+），通过Flo

贵州省数据知识产权登记平台2026-01-07 更新230

Gene expression signature of ex vivo expanded NK cells for 14 days. Gene expression signature of ex vivo expanded NK cells for 14 days

NK细胞扩增

基因表达谱

we performed RNA sequencing to employ an unbiased approach to identify the altered gene expression enhancing the function of ex vivo expanded pNK cells for 14 days, and transcriptionally compared day

NIAID Data Ecosystem40

Table_1_Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21.docx

NK细胞扩增

免疫治疗技术

Background: Natural Killer (NK) cell-based immunotherapy used to treat cancer requires the adoptive transfer of a large number of activated NK cells. Here, we report a new effective method to expand h

NIAID Data Ecosystem20

NK cell expansion on uAPC helper cells. NK cell expansion on uAPC helper cells

NK细胞扩增

CAR-NK细胞疗法

Natural killer (NK) cells are innate lymphocytes recognized for their important role against tumor cells. NK cells expressing chimeric antigen receptors (CARs) have enhanced effector function against

NIAID Data Ecosystem60

Gene expression signature of ex vivo expanded NK cells for 14 days

NK细胞扩增

转录组学分析

we performed RNA sequencing to employ an unbiased approach to identify the altered gene expression enhancing the function of ex vivo expanded pNK cells for 14 days, and transcriptionally compared day

NIAID Data Ecosystem30

Optimization of Expanded NK Cells

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