Supplementary Material for: Psychometric properties of a culturally adapted Spanish version of the Attitudes Toward Genomics and Precision Medicine instrument

Background: There is evidence of growing racial and ethnic disparities in genomic healthcare and precision medicine. Validated survey instruments and measures are required to understand the needs of diverse populations to appropriately tailor person-centered approaches and end disparities in genomic healthcare and precision medicine. Methods: We aimed to examine the psychometric properties of a culturally adapted Spanish version of the Attitudes Toward Genomics and Precision Medicine (AGPM). First, we culturally adapted the AGPM. We then conducted a web-based evaluation of the Spanish AGPM in a cohort of 486 individuals identifying as Hispanic to establish the Spanish version’s reliability, factor structure, and measurement invariance relative to the English version. We also compared AGPM responses between Spanish- and English-speaking Hispanic individuals. Results: The Spanish version of the AGPM demonstrates robust internal consistency with Cronbach alpha ranging from 0.84-0.98 across domains. All AGPM items significantly loaded on their respective factor (p < 0.001). Configural, metric, strict, and residual invariance models all met absolute and relative fit criteria. Significant differences were observed between Spanish and English-speaking participants in some AGPM subscales. Conclusions: The Spanish version of the AGPM demonstrates sound psychometric properties and may be useful for informing culturally empowered approaches to genomic healthcare and precision medicine for people identifying as Hispanic.