A strategy for challenging tumorous bone regeneration by utilizing borosilicate bioactive glass synchronously boosting osteosarcoma combating and osteogenesis promotion of moderate magnetic hyperthermia

To investigate the relevant biological mechanism involved in the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) when cultured with BSG extracts under moderate hyperthermia (42℃, 5%CO2）or regular atmosphere (37℃, 5%CO2 ), the high-throughput RNA sequencing was conducted. Comparative gene expression profiling analysis of RNA-seq data for hBMSCs when cultured with different groups (NC,MSC-HOT, MSC-3BSG, MSC-3BSGHOT). n = 3