Functional analysis of novel RNA binding proteins of Staphylococcus aureus. Staphylococcus aureus

NIAID Data Ecosystem2026-03-10 收录

金黄色葡萄球菌毒力

RNA结合蛋白功能

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https://www.ncbi.nlm.nih.gov/bioproject/PRJDB5479 数据链接链接失效反馈

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Identification and characterization of S. aureus virulence factors is important for understanding S. aureus virulence and establishing therapeutic strategies. The purpose of this project is to reveal the functions of novel RNA binding proteins in S. aureus gene expression.

创建时间：

2019-01-18

Comparison of transcriptomic contents of a wild type Staphylococcus strain (HG001) and the spdC deleted derivative by RNAseq analysis.. Identification of SpdC regulated genes

金黄色葡萄球菌毒力

细菌双组分系统

We have characterized links between the SpdC protein and the WalKR two-component system. We have generated an spdC-deleted strain. This strain behaves like the WT parental strain, at least concerning

NIAID Data Ecosystem70

The RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner

染色质绝缘子调控

RNA结合蛋白功能

Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in

NIAID Data Ecosystem50

This study describes the target receptor and mechanism of action of Staphylococcal superantigen like 13 (SSL13), a secret protein reside on S.aureus immune evasion cluster 2(IEC-2) that previously supposed to modulate immune evasion. In sharp contrast to the characterized SSLs located on the staphylococcal pathogenicity island 2 (SPI-2) , that inhibit immune functions, We demonstrate SSL13 is a chemoattractant and a neutrophil activator that acts via the FPR2. Therefore, SSL13 is a unique SSL member not belonging to the immune evasion class, but is a pathogen alarming molecule sensed by the FPR2. Our study provides a new conception of SSLs, that not only inhibit host immune processes but also recruit human neutrophils to the site of infection, where S. aureus can be disarmed by secreted immune evasion proteins and used as vesicles to other parts of the host. This allow us to better understand of S. aureus pathological processes.

金黄色葡萄球菌毒力

中性粒细胞免疫

Staphylococcal Superantigen-Like (SSL) proteins, one of major virulence factor families produced by Staphylococcus aureus, were previously demonstrated to be immune evasion molecules that interfere wi

NIAID Data Ecosystem20

LINF_250010100

寄生虫分子生物学

RNA结合蛋白功能

RNA-binding protein | UPB1 Leishmania infantum (strain JPCM5)

NIAID Data Ecosystem60

Iron-sensitive RNA regulation by poly C binding proteins [DKD_RNASeq]

铁代谢调控

RNA结合蛋白功能

Iron is important for normal cellular function and posttranscriptional mechanisms regulate the cellular response to iron deficiency. In this study we explore how RNA binding proteins, PCBP1 and PCBP2,

NIAID Data Ecosystem20

Functional analysis of novel RNA binding proteins of Staphylococcus aureus. Staphylococcus aureus

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