X-ray Structure of Polypeptide Deformylase

X-ray Structure of Polypeptide Deformylase Descriptor: (2R)-2-(cyclopentylmethyl)-N'-{5-fluoro-6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-2-methylpyrimidin-4-yl}-3-[hydroxy(hydroxymethyl)amino]propanehydrazide, NICKEL (II) ION, Peptide deformylase Authors: Campobasso, N, Spletstoser, J, Ward, P. Deposit date: 2019-05-09 Release date: 2019-06-26 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections. Bioorg.Med.Chem.Lett., 29, 2019

多肽脱甲酰基酶（Polypeptide Deformylase）X射线晶体结构描述：(2R)-2-(环戊基甲基)-N'-{5-氟-6-[(9aS)-六氢吡嗪并[2,1-c][1,4]恶嗪-8(1H)-基]-2-甲基嘧啶-4-基}-3-[羟基(羟甲基)氨基]丙酰肼、镍(II)离子、多肽脱甲酰基酶。作者：Campobasso, N、Spletstoser, J、Ward, P。提交日期：2019-05-09；发布日期：2019-06-26；最后修改日期：2024-03-13。实验方法：X射线衍射（分辨率1.7 Å）。引用文献：《用于呼吸道与皮肤感染的具有体内活性的哌嗪酸类多肽脱甲酰基酶抑制剂的发现》，《Bioorg.Med.Chem.Lett.》，第29卷，2019年。