Microarray analysis of mouse skeletal muscle atrophied by aging. Mus musculus

Muscle atrophy is associated with aging (sarcopenia) and chronic unloading (such as bed confinement and immobilization with casts), as well as various pathological conditions such as type 1 diabetes and nerve injury (denervation). Skeletal muscle tissues of young mice (13 weeks old, male) and old mice (25 months old, male) were collected and RNA extracted. Expression of Dnmt3a was reduced while expression of Gdf5 was increased in old mice compared to young mice. Overall design: For microarray analysis, Skeletal muscle tissues of young mice (13 weeks old, male) and old mice (25 months old, male) were collected and RNA extracted. Samples from young mice and old mice (young: N = 3, old: N = 3) were use.