Structure of SARS-CoV-2 Spike Protein with Engineered x3 Disulfide (x3(D427C, V987C) and single Arg S1/S2 cleavage site), Closed Conformation

Structure of SARS-CoV-2 Spike Protein with Engineered x3 Disulfide (x3(D427C, V987C) and single Arg S1/S2 cleavage site), Closed Conformation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... Authors: Qu, K, Chen, Q, Ciazynska, K.A, Liu, B, Zhang, X, Wang, J, He, Y, Guan, J, He, J, Liu, T, Zhang, X, Carter, A.P, Xiong, X, Briggs, J.A.G. Deposit date: 2022-05-18 Release date: 2022-07-20 Last modified: 2025-06-18 Method: ELECTRON MICROSCOPY (3 Å) Cite: Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike. Plos Pathog., 18, 2022

本数据集对应经工程化改造的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白结构：该蛋白引入了x3(D427C, V987C)型三对二硫键，并修饰有单精氨酸S1/S2切割位点，呈闭合构象。其所结合的修饰配体包括：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、胆绿素IXα（BILIVERDINE IX ALPHA）等。作者：Qu, K、Chen, Q、Ciazynska, K.A、Liu, B、Zhang, X、Wang, J、He, Y、Guan, J、He, J、Liu, T、Zhang, X、Carter, A.P、Xiong, X、Briggs, J.A.G。提交日期：2022-05-18，发布日期：2022-07-20，最后修改日期：2025-06-18。结构解析方法：电子显微镜（分辨率3 Å）。引用文献："Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike"，发表于Plos Pathog.，2022年，第18卷。