The effect of obestatin contained in the breast milk on the structural and functional development of the offspring in the early postnatal period

Recent studies indicated that obestatin may play a regulatory role in the development of gastrointestinal track in the early postnatal period. The project aimed to understand the effect of obestatin in the development of structure and function ot he small intestine in the early postnatal period. Results shown that enteral administration of obestatin to suckling rats significanlty effects on activity of brush border enzymes, morphometry of intestinal wall as well as small intestinal epithelial renewal. The effect of observed changes was dependent on the segment of intestine studied. Significant changes in the transcriptomic gene profile were founded both in the middle part of intestine and stomach近期研究表明，肥胖抑制素（obestatin）可能在出生后早期的胃肠道发育中发挥调控作用。本项目旨在探究肥胖抑制素在出生后早期小肠结构与功能发育过程中的影响。实验结果显示，对乳鼠经肠内给予肥胖抑制素，可显著影响刷状缘酶活性、肠壁形态计量学指标以及小肠上皮更新过程。所观察到的变化效应因所研究的肠段不同而存在差异；在小肠中段与胃组织中均检测到显著的转录组基因谱变化。