The specific targeting of oncogenic mutant epidermal growth factor receptor (EGFR) is a breakthrough in targeted cancer therapy and marks a drastic change in the treatment of non-small cell lung cance

NIAID Data Ecosystem30

Transcriptome Analysis of Ivosidenib-Mediated Inhibitory Functions on Non-Small Cell Lung Cancer

肺癌药物

差异表达转录组分析

Transcriptome sequencing in Ivosidenib treated NSCLC cells was performed to detect the common differentially expressed mRNAs and non-coding RNAs.

NIAID Data Ecosystem20

PM01183 on SCLC cell lines (ChIP-Seq). PM01183 on SCLC cell lines (ChIP-Seq)

肺癌药物

转录因子结合分析

detect the impact of lurbinectedin on transciption factor binding Overall design: PM01183 on SCLC cell lines

NIAID Data Ecosystem40

DataSheet1_Uncovering the Mechanism of Drug Resistance Caused by the T790M Mutation in EGFR Kinase From Absolute Binding Free Energy Calculations.PDF

EGFR耐药机制

肺癌药物

The emergence of drug resistance may increase the death rates in advanced non-small cell lung cancer (NSCLC) patients. The resistance of erlotinib, the effective first-line antitumor drug for NSCLC wi

NIAID Data Ecosystem20

Classes of compounds that inhibit SCLC cell viability.

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